Rational design

 ( Biotechnology ) 

In chemical biology and biomolecular engineering, rational design ( RD) is an umbrella term which invites the strategy of creating new molecules with a certain functionality, based upon the ability to predict how the molecule's structure (specifically derived from structural motif) will affect its behavior through physical models. This can be done either from scratch or by making calculated variations on a known structure, and usually complements directed evolution.

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Applications As an example, rational design is used to decipher collagen stability, mapping ligand-receptor interactions, unveiling protein folding and dynamics, and creating extra-biological structures by using fluorinated .

Iwao Ojima (2025). 9781405167208, John Wiley & Sons, Ltd., Publications. ISBN 9781405167208

To treat cancer, rational design is used for targeted therapies where proteins are engineered to modify the communication of cells with their environment.

Rebecca Richards-Kortum (2025). 9780521877978, Cambridge University Press. ISBN 9780521877978

There is also the rational design of alfa-alkyl auxin molecules, which are auxin analogs capable of binding and blocking the formation of the hormone receptor complex.

Erich Kombrink (2025). 9782889199280, Frontiers Media SA. ISBN 9782889199280

Other applications of rational design include:

• Protein design
• Nucleic acid design
• Drug design
• Pathway design

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